The following link performs a PMC search on symbol Eicos and its synonyms. Manually annotated information on members of the nuclear receptor superfamily to which this ligand binds. Name Action No enzymes are available for this drug. By submitting this form, you are granting:
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The following link performs a PMC search on symbol Eicos and its synonyms. It also appears to affect the function and bind to the Carbohydrate responsive element binding protein ChREBP and to a fatty acid receptor G-coupled receptor known as GP The aim of EICOS is to provide the methodology, the theoretical and modeling foundations as well as the algorithmic techniques and the necessary software architecture that will facilitate the personalization, integration, and evolution management facilities for information ecosystems that operate over a decentralized infrastructure for a large variety of data types.
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Please click "Refresh" to refresh the page. Name Action No enzymes are available for this drug. Your session has expired.
For website performance, only results containing fold changes or fewer can be viewed in your sicos. Proteins that mediate transmembrane transport of this ligand as curated by DrugBank. NURSA occasionally sends newsletters describing updates to the website, new datasets, funding opportunities, meetings, etc.
The triglyceride-lowering effect of EPA results from inhibition of lipogenesis and stimulation of fatty acid oxidation. In addition, EPA may play a therapeutic role in patients with cystic fibrosis by reducing disease severity and may play a similar role in type 2 diabetics eicso slowing the progression of diabetic nephropathy.
Pharmacological properties of this ligand as curated by DrugBank.
NURSA | Eicos - Eicosapentaenoic acid
Drug targets of this ligand as curated by DrugBank. Enzymatic reactions in which this ligand is a substrate or product as curated by DrugBank. EPA can be used for lowering elevated triglycerides in those who are hyperglyceridemic.
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If these preset parameters retrieve more than fold changes, you will have the option to download the results as an Excel file or adjust the query parameters e. You may unsubscribe via the link found at the bottom of every email. On the other hand, EPA is metabolized to leukotriene B5 LTB5 and thromboxane A3 TXA3which are eicosanoids that promote vasodilation, inhibit platelet aggregation and leukocyte chemotaxis and are anti-artherogenic and anti-thrombotic.
The fundamental idea that will provide the means to achieve eixos above is the concept of dataspace, which involves the structuring of information with semantically rich meta-information, in order to achieve its management in a transparent way, independently of format, structure and origin.
Find genes regulated by this molecule using Transcriptominea tool created by NURSA for mining tissue-specific NR, NR ligand, and coregulator transcriptomes based on published genome wide transcriptional profiling experiments in the field of nuclear receptor signaling.
EPA is a substrate for Prostaglandin-endoperoxide synthase 1 and 2.
Name Source Name Source. This link will take you to a Transcriptomine query page.
Sign up here to receive these newsletters. Emails are serviced by Constant Contact. Collectively the Eocos subfamily plays important roles in lipid and glucose metabolism, and has been implicated in obesity-related metabolic diseases such as hyperlipidemia, insulin resistance, and coronary artery disease.